Twente's miserable run continued when they fell to a 3-0 defeat against Fortuna Sittard last time out. Ron Jans' side have now lost four on the bounce and are winless in nine.
Heracles, who are chasing European football, returned to winning ways last time out when they ran out 4-0 winners against struggling VVV.
However, on the road Heracles have lost three of their last four matches, with the only exception being a 2-1 win at relegation-threatened ADO Den Haag.